COURSE DESIGN

This course is designed for the students having Bachelor degree in any science streams like, biology, chemistry, biotechnology, microbiology, pharmacy, who aspire to make a career in the areas of Research and Development of pharmaceutical sciences with an aim to introduce them at an early stage to the modern concept of Drug Designing. It is expected for the students to have basic knowledge of physical and organic chemistry.
The course has been planned to have both theory and computational lab components. Theory modules will cover the lectures on Basics of CADD which include Pharmacokinetics & Pharmacodynamics with emphasis on Drug action mechanism, theories of drug-receptor interactions. Also includes to learn the fundamental concepts behind the molecular modeling, docking and simulation of biological moleculaes help in understanding structure activity relationship of drug & drug like molecules, and hence act as pillar of the technology.
The course gives equal weightage to theory and practicals. Majority of the lectures are accompanying with the demonstration of the technolgy by an expert, which will help aspirants to understand the fundamental and practical aspects of underlying tools and techniques governing the modern in-silico drug discovery development.This course will help participants to learn about the functioning of various software that are currently being used in the area of Computer Assisted Drug Designing. Participants could come to BISR labs on any weekday to practice the exercises during office hours.)

COURSE OBJECTIVES

The objectives of the course are :-

• To make students learn the science and art of "Drug Designing"
• To make students learn to design and interpret the results of Molecular Modeling calculations
• To have hands on experience with the advanced computational tools available for identifying drug-biomolecule interactions.
• To integrate diverse information into discovery knowledge by exploiting the advantages of emerging fields like Big data, chemo-informatics etc.

LEARNING OUTCOMES:

• Gain a comprehensive understanding of the modern in-silico drug design technology.
• Develop skills in molecular modeling, docking and simulations.
• Learn to analyze QSAR, structure-activity relationships in drug development
• Familiarity with current software and tools used in in-silico drug discovery.

WHO SHOULD ATTEND?

The participants of the course may be UG/PG students and research scholars with background in Life Sciences and/or Information Technology. The course is selfcontained and does not assume any special knowledge of the subject.

MODE OF TRAINING AND TIMINGS

Lectures online and/or onsite at BISR premises, subject to Government regulations. All lecture would be conducted from 4.00 PM to 6 PM on every Friday and Saturday , as per course schedule. In exceptional circumstances they could be rescheduled next available weekday

HOW TO APPLY

Interested candidates may apply through email by attaching the scanned copy of filled application form (fowarded by HoD in case pursuing studies) to radhakishan@bisr.res.in latest by September 20, 2025. The confirmation of participation will be informed through emails only. All aspirants also need to fill the online Google form to timely secure your seat.(First come first serve).
Application closed.

TEACHING FACULTY

Besides BISR faculty, eminent guest speakers from renowned Bioinformatics Centres of India and Industry will deliver lectures and conduct demonstration on various aspects on CADD.

TOPICS COVERED

• Introduction to CADD and Essentials of Bioinformatics & Cheminformatics
• CADD Databases, tools and Resources: PDB, PubChem, UniProt, KEGG, Zinc, DrugBank, Chembl, MMsINC, STITCH, STRING, GENECARD, MALACARDS
• Basic of Drug Discovery Process and Clinical Trials
• Basics of Pharmacology: Pharmacokinetics and Pharmacodynamics, Lipinski Rule of five.
• QSAR, ADME and Toxicity properties of drugs
• Chemistry of drug‐metabolism, drug deactivation and elimination, drug‐receptor interactions
• In-Silico Drug designing approaches: Structure based (Rational), Ligand based, Pharmacophore based methods.
• Drug Targets, Lead Identification & Optimization: Druggable Genome and Known Drug Targets, Pathway Analysis.
• Pharmacophore and Molecular Descriptor Analysis,High-throughput Virtual Screening and Combinatorial Library Designing.
• Molecular Modelling, Docking and Simulations
• Molecular Dynamics Simulation: Forcefield and PE functions. Fine and Coarse grain simulations
• Drug Repurposing, Scaffold Hopping, Multitarget Analysis
• Immunoinformatics and Vaccine Design: Reverse Vaccinology. Multi-Epitope vaccine design
• Bioethics and Drug Regulatory Procedures.
• NGS, Systems Biology and Regulatory Networks in CADD.
• Working with Google Colab & Anaconda, Jupyter Lab, python virtual environments
• Artificial Intelligence(AI) and Machine Learning(ML) in Drug Discovery: Google Colab, Knime, orange tool etc.
• Datamining and Image Processing using Python: ANN and Deep learning Applications
• NLP and its applications in Drug Discovery

click here for detailed modules and practicals

VENUE

Bioinformatics Centre
IInd Floor, R&D Division
Department of Biotechnology
Birla Institute of Scientific Research
Statue Circle, Jaipur 302001

REGISTRATION FEES

Fee: NIL
( Certificate will be given only if a student has minimum 75% attendance and has completed the assignments). Contact Mr Radhakishan for Registration related queries at 9828535532.

NUMBER OF SEATS

Seats are limited to 40 only. This limitation, a unique feature of all BISR training programs, will ensure that participants derive the maximum benefit from the course by enabling them to receive the personal attention of the instructors. Criteria for selection is first-come first-serve.

ORGANIZING COMMITTEE

Convener and Course Coordinator
Dr. P S Solanki
Sr. Scientist,Scientist-Incharge, Bioinformatics Centre
Coordinator, DIC Centre, BISR
Birla Institute of Scientific Research,Statue Circle,Jaipur-302001
Email: pooransingh@bisr.res.in

Course Co-Coordinator
Dr. Raj Kumar Gothwal
Sr. Scientist and Head, Department of Biotechnology
Birla Institute of Scientific Research, Statue Circle, Jaipur
Email: rkgothwal@bisr.res.in

Course Co-Coordinator
Prof S.K. Gupta
Director, Centre for Converging Technologies
Coordinator, Design Innovation Centre (DIC), UoR
Contact No: 0141-2700370, 2700358,
Email Id:- cct.uniraj@gmail.com
University of Rajasthan, Jaipur

Course Co-Coordinator
Prof. Neelima Gupta
Course Coordinator, CADD Module (DIC-RU)
Professor of Chemistry
University of Rajasthan, Jaipur
Email: gupta_neelima@uniraj.ac.in

Course Advisor
Prof. M. Krishna Mohan
Ex. Head, Department of Biotechnology
Birla Institute of Scientific Research, Statue Circle, Jaipur
Email: mkrishnamohan@gmail.com
Cell: +91-9314509942

Other Associated Scientific Staff

• Mr. Radhakishan Meghwanshi
• Ms. Manvi Katiyar

For any registration related query or information, kindly contact radhakishan@bisr.res.in, ( Mobile: +91-9828535532)

DOWNLOADS

(To view these files, you require Adobe Reader, if you don't have, then download it here.)
1. Brochure cum Application Form
2. Course Modules and Practicals

TOP

---

---